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Antagonism is hostility that results in active resistance, opposition, or contentiousness.
Additionally, it may refer to:
- Antagonism (chemistry), where the involvement of multiple agents reduce their overall effect
- Antagonism (philosophy), a principle, force or factor that is an active resistance, opposition, or contentiousness
- Antagonism (pharmacology), when a substance binds to the same site an agonist would bind to without causing activation of the receptor
- Antagonism (phytopathology), the action of any microbes that suppresses the activity of a plant pathogen.